Publications
Scientists and Experts Publish on Unique EsoCap Technology for GI Tract Diseases
The team of scientists at the University of Greifswald and leading experts in the field of platform technology development for targeted drug delivery have published several papers on the unique EsoCap platform technology for the local treatment of eosinophilic esophagitis and patients with upper gastrointestinal tract diseases.
A Leap for Esophageal Health
The publications include the proof-of-concept functionality study conducted in healthy volunteers at the University of Greifswald as well as the acceptance of the EsoCap system in healthy volunteers. The EsoCap platform addresses a broad range of diseases with high unmet medical needs and unsatisfactory treatment options, including GERD, Barrett's disease and esophageal cancer.
Revolutionizing Esophageal Drug Delivery
Researchers at the University of Greifswald have developed and published a biorelevant test system for characterizing esophageal drug delivery systems. This biorelevant assay system allows characterization of the residence time of potential formulations, from small molecules to biologics, including approved and investigational agents, in the esophagus, which is fundamental to the success of local therapy.
Phase II ACESO Trial Ongoing
And finally, the ACESO study design for the Phase II trial that EsoCap is currently conducting with ESO-101 in the lead indication eosinophilic esophagitis (EoE) was recently presented at the EAACI (European Academy of Allergy and Clinical Immunology) Congress.
Papers
Krause, J.; Rosenbaum, C.; Grimm, M.; Rump, A.; Keßler, R.; Hosten, N.; Weitschies, W. The EsoCap-System – An Innovative Platform to Drug Targeting in the Esophagus. J. Control. Release 2020, 327, 1–7, https://doi.org/10.1016/j.jconrel.2020.08.
Rosenbaum, C.; Grimm, M.; Krause, J.; Rump, A.; Kessler, R.; Hosten, N.; Weitschies, W. Functionality and Acceptance of the EsoCap System—A Novel Film-Based Drug Delivery Technology: Results of an In Vivo Study. Pharmaceutics 2021, 13, 828, https://doi.org/10.3390/
Rosenbaum, C.; Großmann, L.; Neumann, E.; Jungfleisch, P.; Türeli, E.; Weitschies, W. Development of a Hot-Melt-Extrusion-Based Spinning Process to Produce Pharmaceutical Fibers and Yarns. Pharmaceutics 2022, 14, 1229, https://doi.org/10.3390/
Rosenbaum, C.M.; Brokmann, F.; Krause, J.; Weitschies, W. Establishment of a Dissolution Test System for the Biorelevant Characterization of Esophageal Applied Dosage Forms. J. Pharm. Sci. 2022, 111, 62–68, https://doi.org/10.1016/j.
Krause, J.; Brokmann, F.; Rosenbaum, C.; Weitschies, W. The Challenges of Drug Delivery to the Esophagus and How to Overcome Them. Expert Opin. Drug Deliv. 2022, 19, 119–131, https://doi.org/10.1080/17425247.2022.
Brokmann, F.; Feindt, F.; Weitschies, W.; Rosenbaum, C. Development of Test Programs for the Biorelevant Characterization of Esophageal-Applied Dosage Forms. Polymers 2023, 15, 3430, https://doi.org/10.1080/17425247.2022.
Posters/Talks
